Multiple Myeloma Treatments

Below are links to information from the National Cancer Institute (NCI) about FDA-approved, commonly used medications for the treatment of multiple myeloma. NCI also has an extensive list of multiple myeloma meds, including many older drugs.

(Maybe the best feature is that the NCI site pronounces the name of the drug for you :)  )

Alkylating Agents

• Alkeran (melphalan)
• Cytoxan (cyclophosphamide)

Antibody Drug Conjugate

• Blenrep (belantamab mafodotin) Note: GSK pulls Blenrep from the US market on Nov. 22, 2022 due to DREAMM-3 clinical trial results

Bi-Specific T-Cell Engager

• Tecvayli (teclistamab)

Bisphosphonates (to treat bone disease, not myeloma itself))

• Aredia (pamidronate disodium)
• Zometa (zoledronic acid)

Cell-Based Gene Therapy

• Abecma (idecabtagene vicleucel, ida cel)
• Carvykti (ciltacabtagene autoleucel, cilta cel)

          LLS Guide to CAR-T therapies

Corticosteroids

• Decadron (dexamethasone)
• Prednisone

COVID-19 Treatment

• Evusheld (combination of tixagevimab and cilgavimab) (for COVID-19 prophylaxis/prevention)
• Paxlovid (nirmatrelvir and ritonavir)

          NIH Information on Anti-SARS-CoV-2 Monoclonal Antibodies

Chromosome Region Maintenance 1 Protein (CRM1) Inhibitor

• Xpovio (selinexor)

Histone Deacetylase (HDAC) Inhibitor

• Farydak (panobinostat) NOTE: FDA withdrew this drug's approval in Nov., 2021

Immunomodulatory Agents

• Pomalyst (pomalidomide)
• Revlimid (lenalidomide)
• Thalomid (thalidomide)

Monoclonal Antibodies

• Darzalex (daratumumab)
• Darzalex Faspro (daratumumab and hyaluronidase)
• Empliciti (elotuzumab)
• Sarclisa (isatuximab)
• Xgeva (denosumab) used in some cases to treat bone disease instead of bisphosphonates

Proteasome Inhibitors

• Kyprolis (carfilzomib)
• Ninlaro (ixazomib citrate)
• Velcade (bortezomib)

 Selective Inhibitor of Nuclear Export

• Xpovio (selinexor)