Multiple Myeloma Treatments

Below are links to information from the National Cancer Institute (NCI) about FDA-approved, commonly used medications for the treatment of multiple myeloma. NCI also has an extensive list of multiple myeloma meds, including many older drugs.

(Maybe the best feature is that the NCI site pronounces the name of the drug for you :)  )

Alkylating Agents

• Alkeran (melphalan)
• Cytoxan (cyclophosphamide)

Antibody Drug Conjugate

• Blenrep (belantamab mafodotin)

Bisphosphonates (to treat bone disease, not myeloma itself))

• Aredia (pamidronate disodium)
• Zometa (zoledronic acid)

Cell-Based Gene Therapy

• Abecma (idecabtagene vicleucel)

Corticosteroids

• Decadron (dexamethasone)
• Prednisone

COVID-19 Treatment

• Regeneron Monoclonal Antibodies Cocktail (casirivimab and imdevimab)

Chromosome Region Maintenance 1 Protein (CRM1) Inhibitor

• Xpovio (selinexor)

Histone Deacetylase (HDAC) Inhibitor

• Farydak (panobinostat)

Immunomodulatory Agents

• Pomalyst (pomalidomide)
• Revlimid (lenalidomide)
• Thalomid (thalidomide)

Monoclonal Antibodies

• Darzalex (daratumumab)
• Darzalex Faspro (daratumumab and hyaluronidase)
• Empliciti (elotuzumab)
• Sarclisa (isatuximab)
• Xgeva (denosumab) used in some cases to treat bone disease instead of bisphosphonates

Peptide Drug Conjugate

• Pepaxto (melphalan flufenamide)

Proteasome Inhibitors

• Kyprolis (carfilzomib)
• Ninlaro (ixazomib citrate)
• Velcade (bortezomib)